Coupling of the nucleus and cytoplasm

  title={Coupling of the nucleus and cytoplasm},
  author={Melissa L Crisp and Qian Liu and Kyle J. Roux and J. B. Rattner and Catherine M Shanahan and Brian G Burke and Phillip D. Stahl and Didier M Hodzic},
  journal={The Journal of Cell Biology},
  pages={41 - 53}
The nuclear envelope defines the barrier between the nucleus and cytoplasm and features inner and outer membranes separated by a perinuclear space (PNS). The inner nuclear membrane contains specific integral proteins that include Sun1 and Sun2. Although the outer nuclear membrane (ONM) is continuous with the endoplasmic reticulum, it is nevertheless enriched in several integral membrane proteins, including nesprin 2 Giant (nesp2G), an 800-kD protein featuring an NH(2)-terminal actin-binding… CONTINUE READING


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