Coupling of the adhesive receptor CD11b/CD18 to functional enhancement of effector macrophage tissue factor response.

@article{Fan1991CouplingOT,
  title={Coupling of the adhesive receptor CD11b/CD18 to functional enhancement of effector macrophage tissue factor response.},
  author={Sheung Tat Fan and Thomas Scott Edgington},
  journal={The Journal of clinical investigation},
  year={1991},
  volume={87 1},
  pages={50-7}
}
Initiation and regulation of localized selective proteolysis is an important effector property of cells of macrophage (Mo) lineage. Among such effector responses is the induced expression of tissue factor (TF) by cells of Mo lineage. In characterizing the regulation of the Mo responses that may influence the magnitude of the effector phase of the cellular immune response, we have identified a role for the cell surface adhesive receptor CD11b/CD18 (Mac-1, CR3) to amplify the induced TF response… CONTINUE READING

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