Coupling of the PTH/PTHrP receptor to multiple G-proteins

Parathyroid hormone (PTH) elicits many of its physiological effects by activating distinct G-proteincoupled signaling cascades that lead to synthesis of cyclic AMP and hydrolysis of phosphatidylinositol 4,5-bisphosphate. Using the nonhydrolyzable photoreactive GTP analog [α-32P]GTP-γ-azidoanilide (GTP-AA) and peptide antisera raised against G-protein… CONTINUE READING