Coupling of tertiary and quaternary changes in human hemoglobin: a 1D and 2D NMR study of hemoglobin Saint Mandé (beta N102Y).

Abstract

Hemoglobin Saint Mandé (beta N102Y) is a low-affinity mutant with the substitution site situated in the quaternary-sensitive alpha 1 beta 2 interface. In adult hemoglobin the Asn102 beta contributes to the stability of the liganded (R) state, forming a hydrogen bond with Asp94 alpha. The quaternary and tertiary perturbations subsequent to the Tyr for Asn… (More)

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Cite this paper

@article{Craescu1990CouplingOT, title={Coupling of tertiary and quaternary changes in human hemoglobin: a 1D and 2D NMR study of hemoglobin Saint Mand{\'e} (beta N102Y).}, author={Constantin T. Craescu and Joel Mispelter and Yves Blouquit}, journal={Biochemistry}, year={1990}, volume={29 16}, pages={3953-8} }