Coupling of ras p21 signalling and GTP hydrolysis by GTPase activating proteins.

@article{Mccormick1992CouplingOR,
  title={Coupling of ras p21 signalling and GTP hydrolysis by GTPase activating proteins.},
  author={Frank Mccormick},
  journal={Philosophical transactions of the Royal Society of London. Series B, Biological sciences},
  year={1992},
  volume={336 1276},
  pages={43-7; discussion 47-8}
}
  • Frank Mccormick
  • Published 1992 in
    Philosophical transactions of the Royal Society…
Ras p21 proteins cycle between inactive, GDP-bound forms and active GTP-bound forms. Hydrolysis of bound GTP to GDP is mediated by proteins referred to as GAPs, two forms of which have been described. The first, p120-GAP, contains regions of homologies with tyrosine kinase oncogenes, and interacts with tyrosine phosphoproteins as well as with ras proteins; p120-GAP may therefore connect signalling pathways that involve tyrosine kinase and ras p21 proteins. The second type of GAP is the product… CONTINUE READING
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