Coupling of planar chromatography to mass spectrometry

  title={Coupling of planar chromatography to mass spectrometry},
  author={G. Morlock and W. Schwack},
  journal={Trends in Analytical Chemistry},
Coupling of planar chromatography to mass spectrometry (MS) and especially ambient MS is a relatively new field of great interest. The direct sample access at ambient conditions and the feasibility to obtain mass spectra free of contamination within a minute or even within seconds greatly contributes to the progress of planar chromatography. Targeted recording of mass spectra on zones of interest is performed after evaluation of the chromatogram, thus providing high efficiency. Reported… Expand
Planar Chromatography Mass Spectrometry
Coupling of planar chromatography with mass spectrometry (thin-layer chromatography/high-performance thin-layer chromatography-mass spectrometry (TLC/HPTLC-MS)) allows highly targeted recording ofExpand
Thin layer chromatography/mass spectrometry.
This review article describes the state of the art of TLC-MS techniques used for indirect and direct characterization of analytes on the surfaces of TLP plates. Expand
PETROLEUM PRODUCTS | Thin-Layer (Planar) Chromatography
Following the instrumental development experienced by thin layer chromatography (TLC) in the last decade, new technology has been used for biodiesel analysis and characterization of crude oils,Expand
Ambient desorption ionization mass spectrometry (DART, DESI) and its bioanalytical applications
In recent years, ambient desorption ionization techniques for mass spectrometry were introduced. Among them, the most established techniques are Direct Analysis in Real Time (DART) and DesorptionExpand
UTLC: An Advanced Technique in Planar Chromatography
As part of increasing research in the field of separation science, there have been many efforts to undertake planar chromatography with more efficient separation and better resolution in the shortestExpand
Advanced Spectroscopic Detectors for Identification and Quantification
Abstract Thin-layer chromatography (TLC) is a technique commonly used to separate chemical and biochemical mixtures on a plate with minimal instrumental requirements. Traditionally, separated sampleExpand
Low-Temperature Plasma Probe Mass Spectrometry for Analytes Separated on Thin-Layer Chromatography Plates: Direct vs Laser Assisted Desorption.
The nature of the TLC plate stationary phase was found to have a significant influence, together with the analyte's characteristics, on the desorption efficiency, and Tandem MS is shown to greatly improve the limits of detection (LODs). Expand
Thin layer chromatography–spray mass spectrometry: a method for easy identification of synthesis products and UV filters from TLC aluminum foils
AbstractA straightforward procedure for direct mass spectrometric (MS) analysis of spots from thin layer chromatography (TLC) plates, without the need of an external ion source, was developed usingExpand
Thin layer chromatography-ion mobility spectrometry (TLC-IMS).
The coupling of the thin-layer chromatography and IMS is reported for the first time, and acceptable separations were achieved for two component mixtures of morphine-papaverine and acridine-pAPaverine. Expand
Dielectric Barrier Discharge Ionization in Characterization of Organic Compounds Separated on Thin-Layer Chromatography Plates
A new method for on-spot detection and characterization of organic compounds resolved on thin layer chromatography (TLC) plates has been proposed. This method combines TLC with dielectric barrierExpand


Planar Chromatography Coupled to Mass Spectrometry
Abstract Applications of thin-layer chromatography/mass spectrometry are expanding rapidly due to commercial availability of the devices, and improved understanding of the procedures required toExpand
Efficacy of planar chromatography coupled to (tandem) mass spectrometry for employment in trace analysis.
HPTLC/MS by a plunger-based extraction device was shown to be an appropriate technique for quantitative planar chromatography, even in trace analysis, and order of sensitivity was shown for the first time in the field of HPTLC/electrospray ionization MS. Expand
New coupling of planar chromatography with direct analysis in real time mass spectrometry.
The coupling of planar chromatography with direct analysis in real time time-of-flight mass spectrometry (DART-TOF-MS) was shown for the first time. Cutting the plate within a track led to substanceExpand
Automated interface for hyphenation of planar chromatography with mass spectrometry.
This universal hands-free interface connects intact normal-phase plates to any liquid chromatography/mass spectrometry (LC/MS) system without any adjustments or modifications to the mass spectrometer. Expand
The state of the art in thin-layer chromatography-mass spectrometry: a critical appraisal.
  • I. Wilson
  • Chemistry, Medicine
  • Journal of chromatography. A
  • 1999
The state of the art of TLC-MS is described and future trends identified. Expand
Mass spectrometric detection for thin-layer chromatographic separations
Abstract Particle-induced desorption mass spectrometry (MS) including fast atom bombardment and laser desorption, is used to sample molecules directly from the surfaces of thin-layer chromatographyExpand
Rotation planar chromatography coupled on-line with atmospheric pressure chemical ionization mass spectrometry.
The coupling of a rotation planar preparative thin-layer chromatography system on-line with mass spectrometry is demonstrated using a simple plumbing scheme and a self-aspirating heated nebulizerExpand
Analysis of Cationic Pesticides by Thin Layer Chromatography/Matrix — Assisted Laser Desorption Ionization Mass Spectrometry
Abstract This study demonstrates the analysis of pesticides by direct coupling of Thin Layer Chromatography (TLC) with Matrix-Assisted Laser Desorption Ionization mass spectrometry (MALDI). TLC-MALDIExpand
On-line overpressure thin-layer chromatographic separation and electrospray mass spectrometric detection of glycolipids.
On-line thin-layer chromatographic separation and electrospray mass spectrometry (TLC/ESI-MS) has been accomplished by direct linking of a commercial overpressure TLC instrument, OPLC 50, and a Q-TOFExpand
Small molecule analysis by MALDI mass spectrometry
This review focuses on the application of matrix assisted laser desorption/ionization (MALDI) mass spectrometry to the characterization of molecules in the low mass range (<1500 Da). Despite itsExpand