Coupling of dopamine receptor subtypes to multiple and diverse G proteins
@article{Sidhu2000CouplingOD, title={Coupling of dopamine receptor subtypes to multiple and diverse G proteins}, author={Anita Sidhu and Hyman B. Niznik}, journal={International Journal of Developmental Neuroscience}, year={2000}, volume={18}, pages={669-677} }
114 Citations
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D5 receptors are required for dopamine and selective D1-like agonists to induce phospholipase C-mediated phosphoinositide signaling in the mammalian brain.
Impaired D2 Dopamine Receptor Function in Mice Lacking Type 5 Adenylyl Cyclase
- Biology, PsychologyThe Journal of Neuroscience
- 2002
Results suggest that AC5 is the principal AC integrating signals from multiple receptors including D1, D2, and A2A in striatum and the cascade involving AC5 among diverse D2 signaling pathways is essential for neuroleptic effects of antipsychotic drugs.
D1 Dopamine Receptor Mediates Dopamine-induced Cytotoxicity via the ERK Signal Cascade*
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In cells transfected with a catalytically defective mutant of MEK1, the upstream ERK-specific kinase, both dopamine- and SKF R-38393-mediated cytotoxicity was markedly attenuated, confirming the participation of the ERK signaling pathway.
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