Coupling of dopamine receptor subtypes to multiple and diverse G proteins

  title={Coupling of dopamine receptor subtypes to multiple and diverse G proteins},
  author={Anita Sidhu and Hyman B. Niznik},
  journal={International Journal of Developmental Neuroscience},
  • A. Sidhu, H. Niznik
  • Published 1 November 2000
  • Biology, Psychology
  • International Journal of Developmental Neuroscience
Pharmacology of signaling induced by dopamine D(1)-like receptor activation.
  • A. S. Undieh
  • Biology, Psychology
    Pharmacology & therapeutics
  • 2010
Novel Dopamine D2 Receptor Signaling through Proteins Interacting with the Third Cytoplasmic Loop
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The dopamine D4 receptor: biochemical and signalling properties
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D5 Dopamine Receptors are Required for Dopaminergic Activation of Phospholipase C
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Impaired D2 Dopamine Receptor Function in Mice Lacking Type 5 Adenylyl Cyclase
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D1 Dopamine Receptor Mediates Dopamine-induced Cytotoxicity via the ERK Signal Cascade*
In cells transfected with a catalytically defective mutant of MEK1, the upstream ERK-specific kinase, both dopamine- and SKF R-38393-mediated cytotoxicity was markedly attenuated, confirming the participation of the ERK signaling pathway.


Coupling of D 1 and Dopamine Receptors to Multiple G Proteins Implications for Understanding the Diversity in Receptor-G Protein Coupling
Dopamine receptors are a subclass of the super family of G protein-coupled receptors, that transduce their effects by coupling to specific G proteins. Within the dopamine receptor family, the
Dopamine receptors: from structure to function.
Target deletion of several of these dopamine receptor genes in mice should provide valuable information about their physiological functions and provide unequivocal evidence for the involvement of one of these receptors in the etiology of various central nervous system disorders.
Dopamine D2 Receptor Isoforms Expressed in AtT20 Cells Differentially Couple to G Proteins to Acutely Inhibit High Voltage‐Activated Calcium Channels
The studies reveal that both D2 isoforms couple to Gαo to partially inhibit this influx through HVA‐CCs, and support the hypothesis of differential coupling of D2 receptor isoforms to G proteins.
Direct protein–protein coupling enables cross-talk between dopamine D5 and γ-aminobutyric acid A receptors
The data highlight a previously unknown signal transduction mechanism whereby subtype-selective G-protein-coupled receptors dynamically regulate synaptic strength independently of classically defined second-messenger systems, and provide a heuristic framework in which to view these receptor systems in the maintenance of psychomotor disease states.
Multiple Coupling of Human D5 Dopamine Receptors to Guanine Nucleotide Binding Proteins GS and Gz
The coupling between human D5 dopamine receptors and G proteins in transfected rat pituitary GH4C1 cells is examined, indicating coupling between D5 and Gzα.
Dopamine D2 receptors in signal transduction and behavior.
Important insights into D2 receptor function in vivo have been obtained by knocking out the D2 gene in mice by identifying the Parkinsonian-like phenotype of D2-null mice and suggesting that these receptors might serve different functions in vivo.
D1 Dopamine Receptors Can Interact with Both Stimulatory and Inhibitory Guanine Nucleotide Binding Proteins
It is demonstrated that D1‐dopaminergic receptors are able to couple to not only stimulatory G proteins, but also to inhibitory G proteins (Gi), which are fully modulated by guanine nucleotides.
G protein-mediated mitogen-activated protein kinase activation by two dopamine D2 receptors.
Results suggest that D2L- and D2S-mediated MAPK activation is predominantly Gbetagamma subunit-mediated signaling and that protein kinase C and tyrosine phosphorylations are involved in these signaling pathways.
Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A
A mechanism previously shown to mediate uncoupling of the β2-adrenergic receptor from Gs and thus heterologous desensitization (PKA-mediated receptor phosphorylation), also serves to ‘switch’ coupling of this receptor fromGs to Gi and initiate a new set of signalling events.
Activation of type II adenylate cyclase by D2 and D4 but not D3 dopamine receptors.
It is proposed that activation of both D2L and D4.4 dopamine receptors potentiated phorbol-12-myristate-13-acetate-stimulated ACII activity through the release of betagamma subunits from pertussis toxin-sensitive G proteins.