Coupling of cholesterol and cone-shaped lipids in bilayers augments membrane permeabilization by the cholesterol-specific toxins streptolysin O and Vibrio cholerae cytolysin.

@article{Zitzer2001CouplingOC,
  title={Coupling of cholesterol and cone-shaped lipids in bilayers augments membrane permeabilization by the cholesterol-specific toxins streptolysin O and Vibrio cholerae cytolysin.},
  author={Alexander Zitzer and Robert Bittman and Christopher A. Verbicky and R K Erukulla and Sucharit Bhakdi and Silvia Weis and Angela Valeva and Michael Palmer},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 18},
  pages={14628-33}
}
Vibrio cholerae cytolysin (VCC) forms oligomeric pores in lipid bilayers containing cholesterol. Membrane permeabilization is inefficient if the sterol is embedded within bilayers prepared from phosphatidylcholine only but is greatly enhanced if the target membrane also contains ceramide. Although the enhancement of VCC action is stereospecific with respect to cholesterol, we show here that no such specificity applies to the two stereocenters in ceramide; all four stereoisomers of ceramide… CONTINUE READING

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