Coupling of cell growth control and apoptosis functions of Id proteins.

@article{Norton1998CouplingOC,
  title={Coupling of cell growth control and apoptosis functions of Id proteins.},
  author={John D. Norton and G T Atherton},
  journal={Molecular and cellular biology},
  year={1998},
  volume={18 4},
  pages={2371-81}
}
The Id family of helix-loop-helix proteins function as negative regulators of cell differentiation and as positive regulators of G1 cell cycle control. We report here that enforced overexpression of the Id3 gene suppresses the colony-forming efficiency of primary rat embryo fibroblasts. Cotransfection with the antiapoptotic Bcl2 or BclXL gene alleviates this suppression and leads to cell immortalization. Consistent with this, enforced expression of Id genes in isolation was found to be a strong… CONTINUE READING