Coupling of cell division to cell growth by translational control of the G1 cyclin CLN3 in yeast.

@article{Polymenis1997CouplingOC,
  title={Coupling of cell division to cell growth by translational control of the G1 cyclin CLN3 in yeast.},
  author={Michael Polymenis and Emmett V. Schmidt},
  journal={Genes & development},
  year={1997},
  volume={11 19},
  pages={2522-31}
}
The eukaryotic cell cycle is driven by a cascade of cyclins and kinase partners including the G1 cyclin Cln3p in yeast. As the first step in this cascade, Cln3p is uniquely positioned to determine the critical growth-rate threshold for division. To analyze factors regulating CLN3 expression, we identified a short upstream open reading frame (uORF) in the 5' leader of CLN3 mRNA as a translational control element. This control element is critical for the growth-dependent regulation of Cln3p… CONTINUE READING

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