Coupling of bone resorption and formation by RANKL reverse signalling

@article{Ikebuchi2018CouplingOB,
  title={Coupling of bone resorption and formation by RANKL reverse signalling},
  author={Yuki Ikebuchi and Shigeki Aoki and Masashi Honma and Madoka Hayashi and Yasutaka Sugamori and Masud K. Khan and Yoshiaki Kariya and Genki Kato and Yasuhiko Tabata and Josef M. Penninger and Nobuyuki Udagawa and Kazuhiro Aoki and Hiroshi Kubiki Suzuki},
  journal={Nature},
  year={2018},
  volume={561},
  pages={195-200}
}
Receptor activator of nuclear factor-kappa B (RANK) ligand (RANKL) binds RANK on the surface of osteoclast precursors to trigger osteoclastogenesis. Recent studies have indicated that osteocytic RANKL has an important role in osteoclastogenesis during bone remodelling; however, the role of osteoblastic RANKL remains unclear. Here we show that vesicular RANK, which is secreted from the maturing osteoclasts, binds osteoblastic RANKL and promotes bone formation by triggering RANKL reverse… CONTINUE READING
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