Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes.

@article{Xiao1999CouplingOB,
  title={Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes.},
  author={Rui Ping Xiao and Pavel V Avdonin and Yu Ying Zhou and Hongfei Cheng and Shahab A. Akhter and Thomas Eschenhagen and Robert J Lefkowitz and Walter J Koch and Edward G. Lakatta},
  journal={Circulation research},
  year={1999},
  volume={84 1},
  pages={
          43-52
        }
}
-Transgenic mouse models have been developed to manipulate beta-adrenergic receptor (betaAR) signal transduction. Although several of these models have altered betaAR subtypes, the specific functional sequelae of betaAR stimulation in murine heart, particularly those of beta2-adrenergic receptor (beta2AR) stimulation, have not been characterized. In the present study, we investigated effects of beta2AR stimulation on contraction, [Ca2+]i transient, and L-type Ca2+ currents (ICa) in single… CONTINUE READING

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