Coupling of activation and inactivation gate in a K+-channel: potassium and ligand sensitivity.

@article{Ader2009CouplingOA,
  title={Coupling of activation and inactivation gate in a K+-channel: potassium and ligand sensitivity.},
  author={Christian Ader and Robert Schneider and S{\"o}nke Hornig and Phanindra Velisetty and Vitya Vardanyan and Karin Giller and Iris Ohmert and Stefan Becker and Olaf Pongs and Marc Baldus},
  journal={The EMBO journal},
  year={2009},
  volume={28 18},
  pages={2825-34}
}
Potassium (K(+))-channel gating is choreographed by a complex interplay between external stimuli, K(+) concentration and lipidic environment. We combined solid-state NMR and electrophysiological experiments on a chimeric KcsA-Kv1.3 channel to delineate K(+), pH and blocker effects on channel structure and function in a membrane setting. Our data show that pH-induced activation is correlated with protonation of glutamate residues at or near the activation gate. Moreover, K(+) and channel… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.
30 Citations
60 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 30 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 60 references

Similar Papers

Loading similar papers…