Coupling of Permeation and Gating in an NMDA-Channel Pore Mutant

Abstract

We report a strong coupling between permeation and gating in a mutant NMDA channel (NR1 N598Q-NR2A). The channel opens to two states that differ by their conductance and, surprisingly, by their selectivity for two permeant monovalent cations, Na+ and Cs+. The two open states are linked to the closed state via a cyclic gating reaction that proceeds… (More)
DOI: 10.1016/S0896-6273(01)80055-6

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