Coupling of NMDA receptors and TRPM4 guides discovery of unconventional neuroprotectants

@article{Yan2020CouplingON,
  title={Coupling of NMDA receptors and TRPM4 guides discovery of unconventional neuroprotectants},
  author={Jing Yan and C. Bengtson and B. Buchthal and Anna M. Hagenston and H. Bading},
  journal={Science},
  year={2020},
  volume={370}
}
Interface targeting skirts excitotoxicity Nearly all attempts to use traditional N-methyl-d-aspartate receptor (NMDAR) antagonists to treat neurodegenerative diseases have failed. This is because NMDARs are not only promoters of neuronal death but also have essential physiological roles in synaptic plasticity and cognitive functions such as learning and memory. Yan et al. explored the structural basis of NMDAR coupling to neuronal cell death (see the Perspective by Jones). The death-promoting… Expand
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