Coupling of Hedgehog and Hippo pathways promotes stem cell maintenance by stimulating proliferation

@inproceedings{Huang2014CouplingOH,
  title={Coupling of Hedgehog and Hippo pathways promotes stem cell maintenance by stimulating proliferation},
  author={Jianhua Huang and Daniel Kalderon},
  booktitle={The Journal of cell biology},
  year={2014}
}
It is essential to define the mechanisms by which external signals regulate adult stem cell numbers, stem cell maintenance, and stem cell proliferation to guide regenerative stem cell therapies and to understand better how cancers originate in stem cells. In this paper, we show that Hedgehog (Hh) signaling in Drosophila melanogaster ovarian follicle stem cells (FSCs) induces the activity of Yorkie (Yki), the transcriptional coactivator of the Hippo pathway, by inducing yki transcription… CONTINUE READING

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