Coupling of Aggregation and Immunogenicity in Biotherapeutics: T- and B-Cell Immune Epitopes May Contain Aggregation-Prone Regions

@article{Kumar2011CouplingOA,
  title={Coupling of Aggregation and Immunogenicity in Biotherapeutics: T- and B-Cell Immune Epitopes May Contain Aggregation-Prone Regions},
  author={Sandeep Kumar and Satish Kumar Singh and Xiaoling Wang and Bonita Rup and Davinder Gill},
  journal={Pharmaceutical Research},
  year={2011},
  volume={28},
  pages={949-961}
}
Biotherapeutics, including recombinant or plasma-derived human proteins and antibody-based molecules, have emerged as an important class of pharmaceuticals. Aggregation and immunogenicity are among the major bottlenecks during discovery and development of biotherapeutics. Computational tools that can predict aggregation prone regions as well as T- and B-cell immune epitopes from protein sequence and structure have become available recently. Here, we describe a potential coupling between… CONTINUE READING
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