Coupling of ATP-sensitive K+ channels to A1 receptors by G proteins in rat ventricular myocytes.

@article{Kirsch1990CouplingOA,
  title={Coupling of ATP-sensitive K+ channels to A1 receptors by G proteins in rat ventricular myocytes.},
  author={Glenn E. Kirsch and Juan Codina and Lutz Birnbaumer and Arthur M. Brown},
  journal={The American journal of physiology},
  year={1990},
  volume={259 3 Pt 2},
  pages={H820-6}
}
ATP-sensitive K+ (K+[ATP]) current is thought to be regulated by GTP-binding proteins (G proteins), but the pathways that couple receptor, G protein, and channel have not been defined. We studied regulation of tolbutamide-sensitive K+[ATP] current in neonatal rat ventricular myocytes. Application of 0.1 mM ATP to the intracellular side of membrane patches reduced K+ [ATP] channel activity, and addition of the nonhydrolyzable GTP analogue guanosine 5'-O-(3-thiotriphosphate) (GTP gamma S) at 0.1… CONTINUE READING

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