Coupling fast water exchange to slow molecular tumbling in Gd3+ chelates: why faster is not always better.

@article{Avedano2013CouplingFW,
  title={Coupling fast water exchange to slow molecular tumbling in Gd3+ chelates: why faster is not always better.},
  author={Stefano Avedano and Mauro Botta and Julian Saunders Haigh and Dario Livio Longo and M. Woods},
  journal={Inorganic chemistry},
  year={2013},
  volume={52 15},
  pages={
          8436-50
        }
}
The influence of dynamics on solution state structure is a widely overlooked consideration in chemistry. Variations in Gd(3+) chelate hydration with changing coordination geometry and dissociative water exchange kinetics substantially impact the effectiveness (or relaxivity) of monohydrated Gd(3+) chelates as T1-shortening contrast agents for MRI. Theory shows that relaxivity is highly dependent upon the Gd(3+)-water proton distance (rGdH), and yet this distance is almost never considered as a… CONTINUE READING
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