Coupling factors in macromolecular type-IV secretion machineries.

  title={Coupling factors in macromolecular type-IV secretion machineries.},
  author={F Xavier Gomis-R{\"u}th and Mar{\'i}a del Mar Sola and F Sebasti{\'a}n de la Cruz and Miquel Coll},
  journal={Current pharmaceutical design},
  volume={10 13},
Type IV secretion systems (T4SSs) are bacterial multiprotein organelles specialised in the transfer of (nucleo)protein complexes across cell membranes. They are essential for conjugation, bacterial-induced tumour formation in plant cells, as observed in Agrobacterium, toxin secretion, like in Bordetella and Helicobacter, cell-to-cell translocation of virulence factors, and intracellular activity of mammalian pathogens like Legionella. By enabling conjugative DNA delivery, these systems… CONTINUE READING
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