Coupling end resection with the checkpoint response at DNA double-strand breaks

Abstract

DNA double-strand breaks (DSBs) are a nasty form of damage that needs to be repaired to ensure genome stability. The DSB ends can undergo a strand-biased nucleolytic processing (resection) to generate 3′-ended single-stranded DNA (ssDNA) that channels DSB repair into homologous recombination. Generation of ssDNA also triggers the activation of the DNA… (More)
DOI: 10.1007/s00018-016-2262-6

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