Coupling diverse routes of calcium entry to mitochondrial dysfunction and glutamate excitotoxicity.

@article{Stanika2009CouplingDR,
  title={Coupling diverse routes of calcium entry to mitochondrial dysfunction and glutamate excitotoxicity.},
  author={Ruslan Iljitsch Stanika and Natalia B. Pivovarova and Christine A. Brantner and Charlotte A Watts and Christine Winters and Stuart B. Andrews},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 24},
  pages={
          9854-9
        }
}
Overactivation of NMDA receptors (NMDARs) is a critical early step in glutamate-evoked excitotoxic injury of CNS neurons. Distinct NMDAR-coupled pathways specified by, for example, receptor location or subunit composition seem to govern glutamate-induced excitotoxic death, but there is much uncertainty concerning the underlying mechanisms of pathway selection. Here we ask whether, and if so how, route-specific vulnerability is coupled to Ca(2+) overload and mitochondrial dysfunction, which is… CONTINUE READING
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