Coupling chromosomal replication to cell growth by the initiator protein DnaA in Escherichia coli.

The initiation of chromosomal replication is strictly controlled during the cell cycle. Its frequency needs to be well-matched to the proliferation rate. In many bacteria, DnaA is the critical mediator in the regulation of replication initiation. In this work, the initiation probability is deduced based on the distribution of DnaA boxes at oriC in… (More)