Coupling cell movement to multicellular development in myxobacteria

@article{Kaiser2003CouplingCM,
  title={Coupling cell movement to multicellular development in myxobacteria},
  author={Dale Kaiser},
  journal={Nature Reviews Microbiology},
  year={2003},
  volume={1},
  pages={45-54}
}
  • D. Kaiser
  • Published 1 October 2003
  • Biology
  • Nature Reviews Microbiology
The myxobacteria are Gram-negative organisms that are capable of multicellular, social behaviour. In the presence of nutrients, swarms of myxobacteria feed cooperatively by sharing extracellular digestive enzymes, and can prey on other bacteria. When the food supply runs low, they initiate a complex developmental programme that culminates in the production of a fruiting body. Myxobacteria move by gliding and have two, polarly positioned engines to control their motility. The two engines undergo… 

Modelling the development of myxobacterial fruiting bodies

Myxobacteria show a complex developmental cycle, which culminates in the formation of multicellular fruiting bodies, and the mechanisms and regulation of this process are tried by means of computational models.

Signaling in myxobacteria.

  • D. Kaiser
  • Biology
    Annual review of microbiology
  • 2004
Traveling waves, streams, and sporulation have increasing thresholds for C-signal activity, and this progression ensures that spores form inside fruiting bodies.

The Dynamics of Myxobacteria Life Cycle

The off-lattice model is developed to simulate the life cycle of Myxococcus xanthus and the Dynamic Energy Budget model is used as a trigger mechanism for cell growth and cell division, and then for switching from the swarming stage to the stage of fruiting body formation.

A New Mechanism for Collective Migration in Myxococcus xanthus

Evidence of a purely mechanical mechanism for collective migration, which is controlled by the cells' length-to-width aspect ratio, is provided by means of numerical simulations of model cell populations where cells interact via volume exclusion.

Myxobacteria: Moving, Killing, Feeding, and Surviving Together

How these social bacteria cooperate and the main cell–cell signaling systems used for communication to maintain multicellularity are reviewed.

From individual cell motility to collective behaviors: insights from a prokaryote, Myxococcus xanthus.

It is suggested that Myxococcus is a powerful system to investigate collective principles that may also be relevant to other cellular systems, including chemotaxis, cell-cell signaling, and the extracellular matrix.

Chemosensory pathways, motility and development in Myxococcus xanthus

The complex life cycle of Myxococcus xanthus includes predation, swarming, fruiting-body formation and sporulation, and at least two of these pathways control gene expression during development.

Dynamics of Fruiting Body Morphogenesis

It is proposed that a model in which both engines stall as the cells' forward progress is blocked by other cells in the traffic jam is eventually circumvented by the cell's capacity to turn, which is facilitated by the push of slime secretion at the rear of each cell and by the flexibility of the myxobacterial cell wall.

Pattern-formation mechanisms in motility mutants of Myxococcus xanthus

It is concluded that unidirectional cell motion induces the formation of large moving clusters at low and intermediate densities, while it results in vortex formation at very high densities.
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