Coupling caspase cleavage and ubiquitin–proteasome-dependent degradation of SSRP1 during apoptosis

@article{Landais2006CouplingCC,
  title={Coupling caspase cleavage and ubiquitin–proteasome-dependent degradation of SSRP1 during apoptosis},
  author={Igor Landais and Hwajin Lee and Huiling Lu},
  journal={Cell Death and Differentiation},
  year={2006},
  volume={13},
  pages={1866-1878}
}
Structure-specific recognition protein (SSRP1) is an 87 kDa protein that heterodimerizes with Spt16 to form FACT, a complex initially shown to facilitate chromatin transcription. Despite its crucial roles in transcription and replication, little is known about the dynamics of FACT turnover in vivo. Here, we show that SSRP1 is cleaved during apoptosis by caspase 3 and/or 7 at the DQHD450 site. Analysis of the resulting fragments suggests that cleavage of SSRP1 generates a truncated, chromatin… CONTINUE READING

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