Coupling among changes in energy metabolism, acid-base homeostasis, and ion fluxes in ischemia.

@article{Katsura1992CouplingAC,
  title={Coupling among changes in energy metabolism, acid-base homeostasis, and ion fluxes in ischemia.},
  author={Kenichiro Katsura and Anders Ekholm and Bo K. Siesj{\"o}},
  journal={Canadian journal of physiology and pharmacology},
  year={1992},
  volume={70 Suppl},
  pages={S170-5}
}
This article attempts correlating changes in cellular energy metabolism, acid-base alterations, and ion homeostasis in ischemia and other conditions. It is emphasized that loss of ion homeostasis, with thermodynamically downhill fluxes of K+, Ca2+, Na+, Cl-, and H+, occurs because energy production fails and (or) ion conductances are increased. In ischemia, energy failure is the leading event but, in hypoglycemia, activation of ion conductances is what precipitates energy failure. The initial… CONTINUE READING