Coupling Reactions of Alkynyl Indoles and CO2 by Bicyclic Guanidine: Origin of Catalytic Activity?

@article{Kee2017CouplingRO,
  title={Coupling Reactions of Alkynyl Indoles and CO2 by Bicyclic Guanidine: Origin of Catalytic Activity?},
  author={Choon Wee Kee and Kai Qi Elizabeth Peh and Ming Wah Wong},
  journal={Chemistry, an Asian journal},
  year={2017},
  volume={12 14},
  pages={1780-1789}
}
Density functional theory calculations were used to investigate the three possible modes of activation for the coupling of CO2 with alkynyl indoles in the presence of a guanidine base. The first of these mechanisms, involving electrophilic activation, was originally proposed by Skrydstrup et al. (Angew. Chem. Int. Ed. 2015, 54, 6682). The second mechanism… CONTINUE READING