Coupling Met to specific pathways results in distinct developmental outcomes.

  title={Coupling Met to specific pathways results in distinct developmental outcomes.},
  author={Flavio Maina and G. Pante and Françoise Helmbacher and Rosa Andres and Annika Porthin and Anthony Mitchell Davies and Carola Ponzetto and Ruediger Klein},
  journal={Molecular cell},
  volume={7 6},
Receptor tyrosine kinases (RTKs) mediate distinct biological responses by stimulating similar intracellular signaling pathways. Whether the specificity of the response is determined by qualitative or quantitative differences in signaling output is not known. We addressed this question in vivo by replacing the multifunctional docking sites of Met, the receptor for hepatocyte growth factor, with specific binding motifs for phosphatidylinositol-3 kinase, Src tyrosine kinase, or Grb2 (Met(2P), Met… CONTINUE READING


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Hepatocyte growth factor - a versatile signal for developing neurons

  • R. Klein
  • Nat . Neurosci .
  • 1999
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