Coupling 40S ribosome recruitment to modification of a cap-binding initiation factor by eIF3 subunit e.

@article{Walsh2014Coupling4R,
  title={Coupling 40S ribosome recruitment to modification of a cap-binding initiation factor by eIF3 subunit e.},
  author={Derek Walsh and Ian J. Mohr},
  journal={Genes & development},
  year={2014},
  volume={28 8},
  pages={
          835-40
        }
}
40S ribosomes are loaded onto capped mRNAs via the multisubunit translation initiation factors eIF3 and eIF4F. While eIF4E is the eIF4F cap recognition component, the eIF4G subunit associates with 40S-bound eIF3. How this intricate process is coordinated remains poorly understood. Here, we identify an eIF3 subunit that regulates eIF4F modification and show that eIF3e is required for inducible eIF4E phosphorylation. Significantly, recruitment of the eIF4E kinase Mnk1 (MAPK signal-integrating… CONTINUE READING
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