Coupled transport of water and ions through membranes as a possible cause of cytotoxic edema.

To clarify the mechanism of cytotoxic edema, NaCl and colloid solutions were separated isoosmotically by an artificial, electronegatively charged membrane. Under control conditions, no fluid movement occurred through the membrane since it was almost impermeable, even to small ions due to high charge density of the membrane. Following elimination of the… CONTINUE READING