Coupled pre-mRNA and mRNA dynamics unveil operational strategies underlying transcriptional responses to stimuli

@inproceedings{Zeisel2011CoupledPA,
  title={Coupled pre-mRNA and mRNA dynamics unveil operational strategies underlying transcriptional responses to stimuli},
  author={Amit Zeisel and Wolfgang J. K{\"o}stler and Natali Molotski and Jonathan M Tsai and Rita Krauthgamer and Jasmine Jacob-Hirsch and Gideon Rechavi and Yoav Soen and Steffen Jung and Yosef Yarden and Eytan Domany},
  booktitle={Molecular systems biology},
  year={2011}
}
Transcriptional responses to extracellular stimuli involve tuning the rates of transcript production and degradation. Here, we show that the time-dependent profiles of these rates can be inferred from simultaneous measurements of precursor mRNA (pre-mRNA) and mature mRNA profiles. Transcriptome-wide measurements demonstrate that genes with similar mRNA profiles often exhibit marked differences in the amplitude and onset of their production rate. The latter is characterized by a large dynamic… CONTINUE READING
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