Coupled positive and negative feedback circuits form an essential building block of cellular signaling pathways.

@article{Kim2007CoupledPA,
  title={Coupled positive and negative feedback circuits form an essential building block of cellular signaling pathways.},
  author={Dongsan Kim and Yung-Keun Kwon and Kwang-Hyun Cho},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  year={2007},
  volume={29 1},
  pages={
          85-90
        }
}
Cellular circuits have positive and negative feedback loops that allow them to respond properly to noisy external stimuli. It is intriguing that such feedback loops exist in many cases in a particular form of coupled positive and negative feedback loops with different time delays. As a result of our mathematical simulations and investigations into various experimental evidences, we found that such coupled feedback circuits can rapidly turn on a reaction to a proper stimulus, robustly maintain… 
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