Coupled phosphatase and kinase switches produce the tristability required for long-term potentiation and long-term depression.

@article{Pi2008CoupledPA,
  title={Coupled phosphatase and kinase switches produce the tristability required for long-term potentiation and long-term depression.},
  author={Hyun Jae Pi and John E. Lisman},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2008},
  volume={28 49},
  pages={13132-8}
}
Studies of long-term potentiation (LTP) and long-term depression (LTD) strongly suggest that individual synapses can be bidirectionally modified. A central question is the biochemical mechanisms that make LTP and LTD persistent. Previous theoretical models have proposed that the autophosphorylation properties of CaMKII could underlie a bistable molecular switch that maintains LTP, and there is experimental support for this mechanism. In contrast, there has been comparatively little theoretical… CONTINUE READING
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