Coupled homologous and nonhomologous repair of a double-strand break preserves genomic integrity in mammalian cells.

@article{Richardson2000CoupledHA,
  title={Coupled homologous and nonhomologous repair of a double-strand break preserves genomic integrity in mammalian cells.},
  author={Christine L Richardson and Maria Jasin},
  journal={Molecular and cellular biology},
  year={2000},
  volume={20 23},
  pages={9068-75}
}
DNA double-strand breaks (DSBs) may be caused by normal metabolic processes or exogenous DNA damaging agents and can promote chromosomal rearrangements, including translocations, deletions, or chromosome loss. In mammalian cells, both homologous recombination and nonhomologous end joining (NHEJ) are important DSB repair pathways for the maintenance of genomic stability. Using a mouse embryonic stem cell system, we previously demonstrated that a DSB in one chromosome can be repaired by… CONTINUE READING
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