Coupled and uncoupled proton movement by amino acid transport system N.

@article{Chaudhry2001CoupledAU,
  title={Coupled and uncoupled proton movement by amino acid transport system N.},
  author={Farrukh Abbas Chaudhry and David Kri{\vz}aj and Peter Larsson and Richard J. Reimer and C Wreden and Jon Storm-Mathisen and David R. Copenhagen and Michael P. Kavanaugh and Robert H Edwards},
  journal={The EMBO journal},
  year={2001},
  volume={20 24},
  pages={7041-51}
}
The system N transporter SN1 has been proposed to mediate the efflux of glutamine from cells required to sustain the urea cycle and the glutamine-glutamate cycle that regenerates glutamate and gamma-aminobutyric acid (GABA) for synaptic release. We now show that SN1 also mediates an ionic conductance activated by glutamine, and this conductance is selective for H(+). Although SN1 couples amino acid uptake to H(+) exchange, the glutamine-gated H(+) conductance is not stoichiometrically coupled… CONTINUE READING