Coupled Sensing of Hunger and Thirst Signals Balances Sugar and Water Consumption

@article{Jourjine2016CoupledSO,
  title={Coupled Sensing of Hunger and Thirst Signals Balances Sugar and Water Consumption},
  author={Nicholas Jourjine and Brendan C. Mullaney and Kevin J. Mann and Kristin Scott},
  journal={Cell},
  year={2016},
  volume={166},
  pages={855-866}
}
Hunger and thirst are ancient homeostatic drives for food and water consumption. Although molecular and neural mechanisms underlying these drives are currently being uncovered, less is known about how hunger and thirst interact. Here, we use molecular genetic, behavioral, and anatomical studies in Drosophila to identify four neurons that modulate food and water consumption. Activation of these neurons promotes sugar consumption and restricts water consumption, whereas inactivation promotes… CONTINUE READING
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