Coupled Equilibrium Model of Hybridization Error for the DNA Microarray and Tag–Antitag Systems

@article{Rose2007CoupledEM,
  title={Coupled Equilibrium Model of Hybridization Error for the DNA Microarray and Tag–Antitag Systems},
  author={J. A. Rose and R. J. Deaton and Masami Hagiya and Akira Suyama},
  journal={IEEE Transactions on NanoBioscience},
  year={2007},
  volume={6},
  pages={18-27}
}
In this work, a detailed coupled equilibrium model is presented for predicting the ensemble average probability of hybridization error per chip-hybridized input strand, providing the first ensemble average method for estimating postannealing microarray/TAT system error rates. Following a detailed presentation of the model and implementation via the software package NucleicPark, under a mismatched statistical zipper model of duplex formation, error response is simulated for both mean-energy and… CONTINUE READING

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