Counting small hypointense spots confounds the quantification of functional islet mass based on islet MRI.

@article{Kim2012CountingSH,
  title={Counting small hypointense spots confounds the quantification of functional islet mass based on islet MRI.},
  author={J H Kim and Sun Mi Jin and Seh Hoon Oh and Seung-Koo Lee and Bae Jun Oh and Soo Kyoung Kim and Sungwook Suh and Jung Hee Lee and Hye Seung Jung and M M-S Lee and M K Lee and K Kim},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2012},
  volume={12 5},
  pages={1303-12}
}
Iron-containing fragmented islets or free iron released from dying cells could confound the interpretation of MRI of iron nanoparticle-labeled islets. Exclusion of small hypointense spots could be a useful strategy to avoid such artifact. We investigated whether this strategy could improve the estimation of functioning islet mass after islet transplantation. Using a rat syngeneic intraportal islet transplantation model, we quantitatively assessed the relationships between total area, number of… CONTINUE READING

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