Counting polymers moving through a single ion channel

  title={Counting polymers moving through a single ion channel},
  author={Sergey M. Bezrukov and Igor Vodyanoy and V. Adrian Parsegian},
THE change in conductance of a small electrolyte-filled capillary owing to the passage of sub-micrometre-sized particles has long been used for particle counting and sizing. A commercial device for such measurements, the Coulter counter, is able to detect particles of sizes down to several tenths of a micrometre1–3. Nuclepore technology (in which pores are etched particle tracks) has extended the lower limit of size detection to 60-nm particles by using a capillary of diameter 0.45 μm (ref. 4… CONTINUE READING

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