Counting human somatic cell replications: methylation mirrors endometrial stem cell divisions.

  title={Counting human somatic cell replications: methylation mirrors endometrial stem cell divisions.},
  author={J Y Kim and Simon Tavar{\'e} and Darryl Shibata},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={102 49},
Cell proliferation may be altered in many diseases, but it is uncertain exactly how to measure total numbers of divisions. Although it is impossible to count every division directly, potentially total numbers of stem cell divisions since birth may be inferred from numbers of somatic errors. The idea is that divisions are surreptitiously recorded by random errors that occur during replication. To test this "molecular clock" hypothesis, epigenetic errors encoded in certain methylation patterns… CONTINUE READING


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