Counting alleles to predict recurrence of early-stage colorectal cancers.

@article{Zhou2002CountingAT,
  title={Counting alleles to predict recurrence of early-stage colorectal cancers.},
  author={Wei Zhou and Steven N. Goodman and Gennaro Galizia and Eva Lieto and Francesca Ferraraccio and Carlo Pignatelli and C. Purdie and J. Piris and Robert Morris and David J. Harrison and Philip B. Paty and Al Culliford and Katharine E. Romans and Elizabeth Anne Montgomery and Michael A. Choti and Kenneth W. Kinzler and Bert Vogelstein},
  journal={Lancet},
  year={2002},
  volume={359 9302},
  pages={219-25}
}
BACKGROUND Chromosome imbalances occur in many cancers and represent important biological properties of tumours. However, measurements of such imbalances are difficult. We used a new, quantitative approach to investigate the prognostic value of chromosome imbalances in early-stage colorectal cancers. METHODS We studied 180 patients with no evidence of lymph-node or distant metastases at the time of surgery. DNA from paraffin-embedded tumours was tested for imbalances of chromosome 8p and 18q… CONTINUE READING

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Chromosome 8 Short ArmAnatomic structure is physical part ofChromosomes
Tumours were divided into three groups : " L " tumours ( n=93 ) had allelic imbalances of chromosomes 8p and 18q , " L / R " tumours ( n=60 ) had allelic imbalances of either chromosome 8p or 18q but not both , and " R " tumours ( n=27 ) retained allelic balance for both chromosomes .
Tumours were divided into three groups : " L " tumours ( n=93 ) had allelic imbalances of chromosomes 8p and 18q , " L / R " tumours ( n=60 ) had allelic imbalances of either chromosome 8p or 18q but not both , and " R " tumours ( n=27 ) retained allelic balance for both chromosomes .
Tumours were divided into three groups : " L " tumours ( n=93 ) had allelic imbalances of chromosomes 8p and 18q , " L / R " tumours ( n=60 ) had allelic imbalances of either chromosome 8p or 18q but not both , and " R " tumours ( n=27 ) retained allelic balance for both chromosomes .
Tumours were divided into three groups : " L " tumours ( n=93 ) had allelic imbalances of chromosomes 8p and 18q , " L / R " tumours ( n=60 ) had allelic imbalances of either chromosome 8p or 18q but not both , and " R " tumours ( n=27 ) retained allelic balance for both chromosomes .
Tumours were divided into three groups : " L " tumours ( n=93 ) had allelic imbalances of chromosomes 8p and 18q , " L / R " tumours ( n=60 ) had allelic imbalances of either chromosome 8p or 18q but not both , and " R " tumours ( n=27 ) retained allelic balance for both chromosomes .
Tumours were divided into three groups : " L " tumours ( n=93 ) had allelic imbalances of chromosomes 8p and 18q , " L / R " tumours ( n=60 ) had allelic imbalances of either chromosome 8p or 18q but not both , and " R " tumours ( n=27 ) retained allelic balance for both chromosomes .
chromosome 18qAnatomic structure is physical part ofChromosomes
Tumours were divided into three groups : " L " tumours ( n=93 ) had allelic imbalances of chromosomes 8p and 18q , " L / R " tumours ( n=60 ) had allelic imbalances of either chromosome 8p or 18q but not both , and " R " tumours ( n=27 ) retained allelic balance for both chromosomes .
Tumours were divided into three groups : " L " tumours ( n=93 ) had allelic imbalances of chromosomes 8p and 18q , " L / R " tumours ( n=60 ) had allelic imbalances of either chromosome 8p or 18q but not both , and " R " tumours ( n=27 ) retained allelic balance for both chromosomes .
Tumours were divided into three groups : " L " tumours ( n=93 ) had allelic imbalances of chromosomes 8p and 18q , " L / R " tumours ( n=60 ) had allelic imbalances of either chromosome 8p or 18q but not both , and " R " tumours ( n=27 ) retained allelic balance for both chromosomes .
Tumours were divided into three groups : " L " tumours ( n=93 ) had allelic imbalances of chromosomes 8p and 18q , " L / R " tumours ( n=60 ) had allelic imbalances of either chromosome 8p or 18q but not both , and " R " tumours ( n=27 ) retained allelic balance for both chromosomes .
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