Counterregulatory adaptation to recurrent hypoglycemia in normal humans.

@article{Davis1991CounterregulatoryAT,
  title={Counterregulatory adaptation to recurrent hypoglycemia in normal humans.},
  author={Mike. Davis and Harry Shamoon},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1991},
  volume={73 5},
  pages={
          995-1001
        }
}
We evaluated the effect of antecedent hypoglycemia on glucose counterregulation during hypoglycemia in non-diabetic human subjects. In single hypoglycemia studies, glucose production [( 3H]3-glucose) and counterregulatory hormone concentrations were measured (after a 3.5-h baseline period of euglycemia) during 120 min of hypoglycemia (glucose clamped at 3.0 mmol/L). During the final 60 min of hypoglycemia, counterregulation resulted in significant increments in glucose production (12.88 +/- 0… CONTINUE READING
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