Counterregulation of interleukin-18 mRNA and protein expression during cutaneous wound repair in mice.

@article{Kmpfer1999CounterregulationOI,
  title={Counterregulation of interleukin-18 mRNA and protein expression during cutaneous wound repair in mice.},
  author={Heiko K{\"a}mpfer and Uwe Kalina and Heiko Muehl and Josef Martin Pfeilschifter and S. P. Frank},
  journal={The Journal of investigative dermatology},
  year={1999},
  volume={113 3},
  pages={369-74}
}
Recent work has suggested interleukin-18 to represent a proinflammatory cytokine that contributes to systemic and local inflammation. As the process of cutaneous wound healing crucially involves an inflammatory phase of repair, we investigated the regulation of interleukin-18 during the repair process. In non-wounded skin we observed high levels of interleukin-18 mRNA, whereas corresponding interleukin-18 protein was expressed only at low basal levels. Upon injury, we found a rapid and large… CONTINUE READING

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