Counterpoint : The Myeloperoxidase 463 G 3 A Polymorphism Does Not Decrease Lung Cancer Susceptibility in Caucasians 1

@inproceedings{Xu2002CounterpointT,
  title={Counterpoint : The Myeloperoxidase 463 G 3 A Polymorphism Does Not Decrease Lung Cancer Susceptibility in Caucasians 1},
  author={L L Xu and Geoffrey L. Liu and David P. Miller and Wei Zhou and Tom J. Lynch and John C. Wain and Li Su and David C. Christiani},
  year={2002}
}
The myeloperoxidase (MPO) G-to-A substitution polymorphism in the promoter region of the MPO gene has been associated with a 40–70% reduction in lung cancer risk in several studies, although a recent nested case-control study disputes these findings. MPO is involved in the activation of a number of procarcinogens, including benzo(a)pyrene. The variant A allele has been shown to reduce MPO mRNA expression, thus potentially decreasing carcinogen activation. To confirm results from smaller studies… CONTINUE READING
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Association of the myeloperoxidase 463G3A polymorphism with lung cancer risk

  • L. Le Marchand, A. Seifried, A. Lunn, L. R. Wilkens
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