Counselling framework for moderate-penetrance cancer-susceptibility mutations

  title={Counselling framework for moderate-penetrance cancer-susceptibility mutations},
  author={Nadine Tung and Susan Domchek and Zsofia Kinga Stadler and Katherine L Nathanson and Fergus J. Couch and Judy E Garber and Kenneth Offit and Mark E. Robson},
  journal={Nature Reviews Clinical Oncology},
The use of multigene panels for the assessment of cancer susceptibility is expanding rapidly in clinical practice, particularly in the USA, despite concerns regarding the uncertain clinical validity for some gene variants and the uncertain clinical utility of most multigene panels. So-called 'moderate-penetrance' gene mutations associated with cancer susceptibility are identified in approximately 2–5% of individuals referred for clinical testing; some of these mutations are potentially… CONTINUE READING
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implications for gene panel testing

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