Coumarin inhibits micronuclei formation induced by benzo(a)pyrene in male but not female ICR mice.

@article{Morris1992CoumarinIM,
  title={Coumarin inhibits micronuclei formation induced by benzo(a)pyrene in male but not female ICR mice.},
  author={Debra L. Morris and J. Barrie Ward},
  journal={Environmental and molecular mutagenesis},
  year={1992},
  volume={19 2},
  pages={
          132-8
        }
}
Coumarin has been shown to be an effective inhibitor of carcinogenesis in rodents if given before and during the carcinogen treatment. We investigated the possibility that pretreatment with coumarin would inhibit the genotoxicity of benzo(a)pyrene (BP) in ICR mice as indicated by the bone marrow micronucleus test, a widely used in vivo test for genotoxicity. Our studies showed that pretreatment of male mice with doses of coumarin at 65 or 130 mg/kg/day for 1 week (with 1 day of no treatment at… CONTINUE READING

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