Coumarin derivatives as potential antitumor agents: Growth inhibition, apoptosis induction and multidrug resistance reverting activity.

@article{Bisi2017CoumarinDA,
  title={Coumarin derivatives as potential antitumor agents: Growth inhibition, apoptosis induction and multidrug resistance reverting activity.},
  author={Alessandra Bisi and Concettina Cappadone and Angela Rampa and Giovanna Farruggia and Azzurra Sargenti and Federica Belluti and Rita Maria Concetta Di Martino and Emil Malucelli and Alessia Meluzzi and Stefano Iotti and Silvia Gobbi},
  journal={European journal of medicinal chemistry},
  year={2017},
  volume={127},
  pages={577-585}
}
A small library of coumarins, carrying butynyl-amino chains, was synthesized continuing our studies in the field of MDR reverting ageEnts and in order to obtain multipotent agents to combat malignancies. In particular, the reported anticancer and chemopreventive natural product 7-isopentenyloxycoumarin was linked to different terminal amines, selected on the basis of our previously reported results. The anticancer behaviour and the MDR reverting ability of the new compounds were evaluated on… CONTINUE READING

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