Coulomb blockage of hybridization in two-dimensional DNA arrays.


Experiments on DNA microarrays have revealed substantial differences in hybridization thermodynamics between DNA free in solution and surface tethered DNA. Here we develop a mean field model of the Coulomb effects in two-dimensional DNA arrays to understand the binding isotherms and thermal denaturation of the double helix. We find that the electrostatic… (More)


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@article{Vainrub2002CoulombBO, title={Coulomb blockage of hybridization in two-dimensional DNA arrays.}, author={Arnold Vainrub and B. Montgomery Pettitt}, journal={Physical review. E, Statistical, nonlinear, and soft matter physics}, year={2002}, volume={66 4 Pt 1}, pages={041905} }