Could Vitamin C deficiency have a role in shaken baby syndrome?

  title={Could Vitamin C deficiency have a role in shaken baby syndrome?},
  author={Eva Lai-wah Fung and Edmund Anthony Severn Nelson},
  journal={Pediatrics International},
Unexplained subdural hematoma in infants, with or without retinal hemorrhages and skeletal fracture, has been considered by some to be pathognomic for non-accidental injury (Fig. 1). However, there is increasing concern that the exact pathogenesis of these findings is not well understood. Dr Clemeston has proposed that some of these cases of presumed shaken baby syndrome (SBS) were due to vitamin C deficiency, and has recommended that plasma ascorbic acid and whole blood histamine should be… Expand
Retinal Hemorrhage in Abusive Head Trauma
Clinicians can confidently rely on a large and solid evidence base when assessing the implications of retinal hemorrhage in children with concern of possible child abuse. Expand
Evaluation of a Temporal Association between Vaccination and Subdural Hematoma in Infants.
No significant temporal association between vaccination and subdural hematoma diagnosis is found, which must continue to be considered a red flag for abusive head trauma and child abuse. Expand
Evaluation of Temporal Association Between Vaccinations and Retinal Hemorrhage in Children.
Ophthalmologists noting incidental retinal hemorrhage on an outpatient examination should consider a child abuse evaluation in the absence of other known ocular or medical disease. Expand
Pediatric reference intervals for lymphocyte vitamin C (ascorbic acid).
Pediatric reference ranges for lymphocyte vitamin C in healthy, fasted children at a relevant age group (0-7 years) can now be used to more reliably explore possible implications of variation of vitamin C levels on bleeding and other clinical signs. Expand
Síndrome del bebé sacudido: ¿es posible el diagnóstico diferencial?
The literature about the appearance of the symptomatic triad that makes up the syndrome is reviewed, and the presence of some of these injuries in other illnesses or accidents, in order to make the right differential diagnosis, and therefore minimize the risk of future shaking, and to take appropriate medical, psychological, social and legal measures. Expand


Barlow's disease.
The classical form of Barlow's disease or infantile scurvy, with bruises, broken bones and sores that will not heal, is rarely seen today, but it seems to be reappearing under a different guise, whenExpand
A painful limp
A healthy 18‐month‐old child who developed a painful limp, without a history of trauma or fever, was described, and diagnosis was confirmed by blood tests and by a rapid recovery following replacement therapy. Expand
Post mortem tissue levels of ascorbic acid in a scurvy case.
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The analytical procedure used to determine the levels of Vitamin C in autopsy samples utilized a sensitive amino-bonded reverse-phase high-performance liquid chromatographic (HPLC) technique. Expand
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It is postulated that the rate of recovery from capillary trauma inflicted by the test was dependent upon the function of ascorbic acid in the hydroxylation of proline to hydroxyproline during collagen synthesis. Expand
Plasma Vitamin C Levels Are Decreased and Correlated With Brain Damage in Patients With Intracranial Hemorrhage or Head Trauma
Findings suggest that a condition of oxidative stress occurs in patients with head trauma and hemorrhagic stroke of recent onset, and AA levels were significantly inversely correlated with the severity of the neurological impairment. Expand
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Since Caffey’s paper on the association between fractures of the long bones and subdural haematoma, published in 1946, many reports of the skeletal injuries in the radiological and paediatric literature are reported. Expand
Blood vitamin concentrations during the acute‐phase response
Recommendations regarding daily supplementation with these vitamins in clinical practice cannot be made on the basis of these results, as the functional importance of these observations is not, at present, clear. Expand
Ascorbic acid status: biochemical and clinical considerations.
Chemical and physiological factors combined with the rapid movement of the vitamin between plasma and cells suggest that a reliable indicator of AA status remains to be identified. Expand
Histamine and ascorbic acid in human blood.
Analysis of 437 human blood samples has shown that when the plasma-reduced ascorbic acid level falls below 1 mg/100 ml, the whole blood histamine level increases exponentially as the ascorbic acidExpand