Could Some Nonhemostatic Plasma Proteins Serve as Refuse Collectors for Fibrin(ogen)?

@article{Litvinov2019CouldSN,
  title={Could Some Nonhemostatic Plasma Proteins Serve as Refuse Collectors for Fibrin(ogen)?},
  author={Rustem I. Litvinov and John W. Weisel},
  journal={Thrombosis and haemostasis},
  year={2019}
}
In the October issue of Thrombosis and Haemostasis, Talens et al1 proposed a general physiological role for certain plasma proteins previously shown to bind strongly but noncovalently to fibrinogen and/or fibrin. After excluding the proteins with known hemostatic activities, the authors recognized that some of the remainingfibrin-bound proteins (clusterin, haptoglobin,α2-macroglobulin, apolipoproteins E and AI, albumin, serum amyloid P, and α1-antitrypsin) belong to a familyof “extracellular… 

Rupture of blood clots: Mechanics and pathophysiology

Toughness, i.e., resistance to rupture, quantified by the critical energy release rate of physiologically relevant fibrin gels was determined to be 7.6 ± 0.45 J/m2, and it was shown that breaking of fibers ahead the crack at a critical stretch is the mechanism of rupture of blood clots, including thrombotic embolization.

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